No ka mālama ʻana i ka mycoplasma holoholona a me ka manu a me nā maʻi bacteria koʻikoʻi, e like me ka maʻi pasteurella, mastitis, endometritis, peritonitis, sepsis, ka maʻi hanu a me ka digestive a me ka urnary tract i hoʻokumu ʻia e nā ʻano maʻalahi; puaʻa atrophic rhinitis, maʻi streptococcal, puaʻa toxoplasmosis, coccidiosis, maʻi hanu mau o ka moa a me ka maʻi rhinitis.
Loaʻa iā Oxytetracycline a me tylosin ka hopena synergistic, hoʻohana ʻia no nā bacteria Gram-positive, Gram-negative bacteria a me ka maʻi mycoplasma. E like me E. coli a i ʻole Salmonella pullorun i hana i nā ʻōpala bipi, ka dysentery hipa, ka maʻi diarrhea melemele bacillary a me ka maʻi diarrhea keʻokeʻo bacillary o ka piglet, ka maʻi diarrhea keʻokeʻo i nā moa a pēlā aku;
Ua hoʻoulu ʻo Pasteurellamultocida i ka bovine hemorrhagic septicemia, ka maʻi puaʻa, ka cholera avium a pēlā aku; ua hoʻoulu ʻo mycoplasma i ka pneumonia pipi, ka pneumonia enzootic puaʻa a me nā maʻi hanu maʻi moa. Hoʻopilikia ʻia e ka hematocytozoon o gonderiosis, actinomycetes, leptospirosis, a loaʻa pū kekahi hopena.