Niclosamide Bolus 1250 mg
Hoʻopaʻa ʻo Niclosamide Bolus i ka phosphorylation i loko o ka mitochondria o nā cestodes. ʻO nā mea ʻelua ma vitro a me vivo, ua make nā ʻāpana scolex a me proximal i ka wā e pili ai me ka lāʻau. Hiki ke hoʻoheheʻe ʻia ka scolex i hoʻokuʻu ʻia i loko o ka ʻōpū; no laila, he mea hiki ʻole ke ʻike i ka scolex i loko o nā feces. He taenicidal ka Niclosamide Bolus i ka hana a hoʻopau ʻaʻole wale i nā ʻāpana akā ʻo ka scolex pū kekahi.
ʻIke ʻia ka hana a Niclosamide Bolus e kūʻē i nā ilo ma muli o ke kāohi ʻana o ka mitochondrial oxidative phosphorylation; ua hoʻopilikia ʻia hoʻi ka hana ʻana o ka ATP anaerobic.
ʻO ka hana cestocidal o Niclosamide Bolus ma muli o ke kāohi ʻana i ka omo ʻana o ka glucose e ka tapeworm a me ka wehe ʻana o ke kaʻina hana phosphorylation oxidative i loko o ka mitochondria o cestodes. ʻO ka waikawa lactic i hōʻiliʻili ʻia ma muli o ke ālai ʻana o ke kaʻina hana Krebs e pepehi i nā ilo.
Nā hōʻailona
Ua hōʻike ʻia ʻo Niclosamide Bolus no ka hoʻouka ʻana o nā holoholona, nā manu, nā ʻīlio a me nā pōpoki i ka tapeworm a me ka paramphistomiasis immature (Amphistomiasis) o nā pipi, nā hipa a me nā kao.
Nā ilo lipine
Nā Pipi, nā Hipa Kao a me nā Dia: Moniezia Species Thysanosoma (Fringed Tape worms)
ʻĪlio: Dipylidium Caninum, Taenia Pisiformis T. hydatigena a me T. taeniaeformis.
Nā LioNā maʻi ʻAnoplocephalid
ManuʻO Raillietina lāua ʻo Davainea
ʻAmphistomasis: (Nā Paramphistomes ʻŌpiopio)
I loko o nā bipi a me nā hipa, he mea maʻamau loa nā flukes Rumen (Paramphistomum species). ʻOiai ʻo nā flukes makua i hoʻopili ʻia i ka paia rumen he mea liʻiliʻi paha, ʻo nā mea ʻōpiopio he pathogenic koʻikoʻi e hōʻino nui ana a make i ka wā e neʻe ana i loko o ka paia duodenal.
Pono e kānalua ʻia nā holoholona e hōʻike ana i nā hōʻailona o ka anorexia koʻikoʻi, ka nui o ka inu ʻana i ka wai, a me ka maʻi kahe wai ʻino no ka amphistomiasis a mālama koke ʻia me Niclosamide Bolus e pale aku i ka make a me ka nalowale o ka hana ʻana no ka mea hāʻawi mau ʻo Niclosamide Bolus i ka hopena kiʻekiʻe loa e kūʻē i nā flukes ʻōpiopio.
Hoʻonohonoho ʻana
Aia kēlā me kēia bolus i uhi ʻole ʻia:
Niclosamide IP 1.0 gm
Ka hoʻokele a me ka dosage
ʻO Niclosamide Bolus i ka meaʻai a i ʻole e like me ia.
E kū'ē i nā ilo liʻiliʻi
Pipi, Hipa a me Lio: 1 gm bolus no 20 kg ke kaumaha o ke kino
Nā ʻīlio a me nā pōpoki1 gm bolus no ke kaumaha o ke kino he 10 kg
Manu1 gm bolus no 5 mau manu makua
(Ma kahi o 175 mg no kg ke kaumaha o ke kino)
E kūʻē i nā Amphistomes
Pipi a me nā Hipa:ʻOi aku ka nui o ka lāʻau ma ka helu o 1.0 gm bolus / 10 kg ke kaumaha o ke kino.
Palekana:He ākea ka palekana o ka Niclosamide bolus. ʻO ka hoʻonui ʻia ʻana o ka Niclosamide a hiki i 40 mau manawa i nā hipa a me nā bipi ua ʻike ʻia he ʻawaʻawa ʻole. I loko o nā ʻīlio a me nā pōpoki, ʻelua ka nui o ka lāʻau i ʻōlelo ʻia ʻaʻole ia e hoʻoulu i nā hopena maikaʻi ʻole koe wale nō ka palupalu o nā ʻōpala. Hiki ke hoʻohana palekana ʻia ka Niclosamide bolus i nā pae āpau o ka hāpai ʻana a i nā mea nāwaliwali me ka ʻole o nā hopena maikaʻi ʻole.
