ʻO Colistin Sulfate Pharmacology & Practical Clinical Formulation Guide no nā Kauka Lapaʻau

He mea hoʻohana nui ʻia ʻo Colistin sulfate no ka pale ʻana i nā maʻi bacteria i nā mahiʻai holoholona. Eia nō naʻe, ʻike wale ka hapa nui o nā mahiʻai a me nā kauka holoholona i kona inoa me ka ʻole o ka hoʻomaopopo ʻana i ka hoʻohana maʻamau a kikoʻī. Ma ka hoʻomaopopo pono ʻana i kona mau waiwai antibacterial, ka hoʻohana ʻana i nā hui i kuhikuhi ʻia a me ka hoʻokele maʻamau hiki iā mākou ke hoʻonui i kona pono lapaʻau e hoʻokō i ka pane wikiwiki a me nā helu ho'ōla kiʻekiʻe.

ʻAʻole hilinaʻi ka lāʻau lapaʻau holoholona maikaʻi i nā kumukūʻai haʻahaʻa, akā, ʻo ka ʻike pono ʻana i nā waiwai o ka lāʻau. ʻO ka hohonu o kou ʻike ʻana i kahi lāʻau, ʻoi aku ka pololei o kāu koho ʻana i ka lāʻau a me ka lawelawe ʻana, e kau ana i kahi kahua paʻa no ka ʻike ʻana i ka maʻi a me ka mālama ʻana. ʻO ka pauka soluble Colistin sulfate kahi lāʻau lapaʻau ʻōpū maʻamau i ka mālama ʻana i nā manu lapaʻau a me nā holoholona, ​​akā, he kakaikahi nā mea hana mua e hoʻomaopopo pono i kona mau waiwai a me nā lula kūlike maʻamau.

1. Ka ʻike ʻana i nā mea maka a me ka hoʻokaʻawale ʻana i ka maikaʻi o ka huahana

ʻO Colistin sulfate kahi antibiotic polypeptide alkaline kūlohelohe i unuhi ʻia ma o ka fermentation biological. ʻO kāna huahana maʻemaʻe maʻamau he pauka keʻokeʻo, hiki ke hoʻoheheʻe ʻia i ka wai maʻemaʻe, a aneane hiki ʻole ke hoʻoheheʻe ʻia i nā mea hoʻoheheʻe organik āpau. ʻIke ʻia kekahi mau huahana pauka colistin sulfate kalepa he melemele, ʻulaʻula a poni paha i ka wā i wehe ʻia ai. ʻAʻole hiki i kēlā mau huahana ke hoʻokō i nā kūlana maʻemaʻe o nā mea maka a helu ʻia he mau waiwai haʻahaʻa, ʻaʻole i ʻōlelo ʻia no ka hoʻohana lapaʻau. Ma muli o kona solubility haʻahaʻa i nā mea hoʻoheheʻe organik, mai hui pū me nā ʻano wai i loaʻa nā kiʻekiʻe o nā mea hoʻoheheʻe organik i ka wā e hoʻomākaukau ai i nā lāʻau lapaʻau hui wai inu. ʻOiai inā ʻaʻohe stratification a i ʻole ka ua ʻike ʻia ma hope o ka hui ʻana, e hoʻemi nui ʻia ka hana bactericidal o colistin sulfate ma hope o ke komo ʻana i ka ʻōpū digestive o nā holoholona a me nā manu. No nā kauka holoholona mua e manaʻo nei e hōʻoia i nā hopena therapeutic, ʻo ka hoʻonohonoho ʻana i nā huahana lāʻau lapaʻau kūpono ka hana koʻikoʻi mua. ʻO ka hoʻohālikelike ʻana i nā lāʻau lapaʻau kūpono e pili ana i kā lākou mau waiwai physicochemical a me ka hoʻohālikelike ʻana i nā kaʻina hana hui a me ka hoʻokele ʻana e hana i ka hōʻoia kumu o nā hopena curative paʻa.

2. ʻAno hana bactericidal a me ka antibacterial spectrum

ʻO ke ʻano hana bactericidal ikaika o ka colistin sulfate: Ma hope o ka hana ʻana ma luna o ka bacteria, hōʻino mau ka lāʻau i ke ʻano o ka membrane cell o ka bacteria Gram-negative a hoʻonui nui i ka permeability membrane. ʻO nā mea intracellular koʻikoʻi e like me nā ion potassium, nā ion calcium, nā waikawa amino, nā purines a me nā pyrimidines e hoʻokahe mau ana i waho, e hoʻopau ana i nā mea nuklea a me nā ribosomes a hoʻoulu i ka lysis bacteria wikiwiki a me ka make. Loaʻa i kēia lāʻau kahi spectrum antibacterial haiki a hoʻokō wale i ka hana ikaika e kūʻē i nā pathogens Gram-negative maʻamau i ka hānau ʻana, me Escherichia coli, Salmonella, Proteus, Shigella, Pasteurella a me Pseudomonas aeruginosa. ʻO kāna ʻano bactericidal kū hoʻokahi e paʻakikī ai i nā bacteria pathogenic ke hoʻomohala i ke kūʻē ʻana i ka lāʻau e kūʻē i ka colistin sulfate. Eia kekahi, ʻaʻohe ona kūʻē keʻa me ka hapa nui o nā antibiotics me nā palena hoʻohālikelike liʻiliʻi, e ʻae ana i nā hoʻolālā combinatorial maʻalahi.

3. Nā ʻano o ka hoʻopili ʻana o In Vivo no ke alakaʻi ʻana i nā lāʻau lapaʻau i hui pū ʻia

Ke hāʻawi waha ʻia i nā holoholona a me nā manu olakino, ʻaneʻane komo ka colistin sulfate i loko o ka mucosa ʻōpū e komo i ke kahe koko. I nā hihia o ka enteritis a i ʻole enterotoxemia me ka uhi ʻōpū i hōʻino ʻia a hyperpermeable, hiki ke komo ma kahi o 10% o ka lāʻau lapaʻau waha i loko o ke koko. Hāʻawi kēia ʻano i kahi kumu kumumanaʻo no ka lāʻau lapaʻau i hui pū ʻia e pili ana i nā maʻi ʻōpū i hoʻopilikia ʻia e nā maʻi lua systemic. Mālama ka lāʻau i ka nui kūloko kiʻekiʻe ma nā ʻeha ʻōpū e kāohi i ka bacteria, ʻoiai ʻo ka hapa liʻiliʻi i hoʻopili ʻia e kāohi i ka maʻi lua systemic, e hāʻawi ana i nā hopena therapeutic pālua.

4. Nā ʻano hoʻohālikelike hoʻohālikelike lapaʻau Synergistic maʻamau

CʻO ka hui ʻana o ka colistin sulfate me nā sulfonamides a me nā trimethoprim potentiators e hāʻawi i nā hopena bactericidal synergistic koʻikoʻi e kūʻē i nā maʻi i hoʻoulu ʻia e Escherichia coli, Pasteurella, Salmonella, Klebsiella pneumoniae a me Pseudomonas aeruginosa. ʻOi aku ka maikaʻi o ka hopena therapeutic piha ma mua o ka hoʻokele colistin sulfate hoʻokahi.

Ma ke ʻano he lāʻau lapaʻau holoholona ʻoihanaʻOEMmea hana e hoʻolako ana i nā huahana moʻo colistin sulfate no ka honua holoʻokoʻaB2Bnā mea hoʻolaha holoholona,HEBEI LIHUA PHARMACEUTICAL CO., LTDHāʻawi i ke kākoʻo piha me ka nānā ʻana i nā mea maka, ka hoʻohuihui maʻamau a me ka lako nui paʻa no ka mahiʻai moa, puaʻa, hipa a me ke keiki bipi. E kāhea iā mākou no nā pepa ʻikepili loea a me nā hoʻonā hana like OEM.